Lidocaine hydrochloride

Research use only, not for human use.

Lidocaine HCl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo.

Lidocaine HCl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.

Cell Proliferation Assay Cell Line:The human gastric cancer cell line MKN45 Concentration:10?nM Incubation Time:48 hours Result:Decreased significantly cell proliferation.Cell Viability Assay Cell Line:The human gastric cancer cell line MKN45 Concentration:1, 5 and 10?nM Incubation Time:24, 48, 72 hours Result:Inhibited MKN45 cell viability.Apoptosis Analysis Cell Line:The human gastric cancer cell line MKN45 Concentration:10?nM Incubation Time:48 hours Result:Increased significantly the apoptotic cell rate.Western Blot Analysis Cell Line:The human gastric cancer cell line MKN45 Concentration:10?nM Incubation Time:48 hours Result:Down-regulated Cyclin D1 and up-regulated p21 expression significantly.

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Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

Inflammation/Immunology

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73-78-9

270.8

C14H22N2O·HCl

>98% (HPLC)

Soluble in DMSO

Cl.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C

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(-20℃)

With Ice Pack

≥ 2 years